Brain atrophy and white matter hyperintensities in early Parkinson's disease
Identifieur interne : 000B52 ( Main/Exploration ); précédent : 000B51; suivant : 000B53Brain atrophy and white matter hyperintensities in early Parkinson's disease
Auteurs : Turi O. Dalaker [États-Unis, Norvège] ; Jan P. Larsen [Norvège] ; Niels Bergsland [États-Unis] ; Mona K. Beyer [Norvège] ; Guido Alves [Norvège] ; Michael G. Dwyer [États-Unis] ; Ole-Bjorn Tysnes [Norvège] ; Ralph H. B. Benedict [États-Unis] ; Arpad Kelemen [États-Unis] ; Kolbjorn Bronnick [Norvège] ; Robert Zivadinov [États-Unis]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-11-15.
English descriptors
Abstract
The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age‐matched NC. On 3D‐T1‐WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention‐executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. We conclude that global structural brain changes are not a major feature in patients with incident PD. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22754
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-11-15">2009-11-15</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">15</biblScope><biblScope unit="page" from="2233">2233</biblScope><biblScope unit="page" to="2241">2241</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">C02DE818BF537E2F5D675023C45334276547BA43</idno><idno type="DOI">10.1002/mds.22754</idno><idno type="ArticleID">MDS22754</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>MRI</term><term>Parkinson's disease</term><term>SIENAX</term><term>brain atrophy</term><term>cognition</term><term>white matter hyperintensities</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The purpose of this research was to examine the extent of global brain atrophy and white matter hyperintensities (WMH) in early Parkinson's disease (PD) compared to normal controls (NC), to explore the relationship between the MRI variables and cognition in PD. In this multicenter study we included 155 PD patients (age 65.6 ± 9.1 years, disease duration 26.7 ± 19.9 months) and 101 age‐matched NC. On 3D‐T1‐WI, we calculated normalized brain volumes using SIENAX software. WMH volumes were assessed semiautomatically. In PD patients, correlation and regression analyses investigated the association between atrophy and WMH outcomes and global, attention‐executive, visuospatial, and memory cognitive functions. Regression analysis was controlled for age, education, depression score, motor severity, cerebrovascular risk, and sex. No significant MRI variable volume group differences were found. The models did not retain any of the imaging variables as significant predictors of cognitive impairment. There was no evidence of brain atrophy or higher WMH volume in PD compared to NC, and MRI volumetric measurements were not significant predictors of cognitive functions in PD patients. We conclude that global structural brain changes are not a major feature in patients with incident PD. © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Norvège</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="États-Unis"><region name="État de New York"><name sortKey="Dalaker, Turi O" sort="Dalaker, Turi O" uniqKey="Dalaker T" first="Turi O." last="Dalaker">Turi O. Dalaker</name></region><name sortKey="Benedict, Ralph H B" sort="Benedict, Ralph H B" uniqKey="Benedict R" first="Ralph H. B." last="Benedict">Ralph H. B. Benedict</name><name sortKey="Benedict, Ralph H B" sort="Benedict, Ralph H B" uniqKey="Benedict R" first="Ralph H. B." last="Benedict">Ralph H. B. Benedict</name><name sortKey="Bergsland, Niels" sort="Bergsland, Niels" uniqKey="Bergsland N" first="Niels" last="Bergsland">Niels Bergsland</name><name sortKey="Dwyer, Michael G" sort="Dwyer, Michael G" uniqKey="Dwyer M" first="Michael G." last="Dwyer">Michael G. Dwyer</name><name sortKey="Kelemen, Arpad" sort="Kelemen, Arpad" uniqKey="Kelemen A" first="Arpad" last="Kelemen">Arpad Kelemen</name><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name><name sortKey="Zivadinov, Robert" sort="Zivadinov, Robert" uniqKey="Zivadinov R" first="Robert" last="Zivadinov">Robert Zivadinov</name></country><country name="Norvège"><noRegion><name sortKey="Dalaker, Turi O" sort="Dalaker, Turi O" uniqKey="Dalaker T" first="Turi O." last="Dalaker">Turi O. Dalaker</name></noRegion><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name><name sortKey="Alves, Guido" sort="Alves, Guido" uniqKey="Alves G" first="Guido" last="Alves">Guido Alves</name><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K." last="Beyer">Mona K. Beyer</name><name sortKey="Beyer, Mona K" sort="Beyer, Mona K" uniqKey="Beyer M" first="Mona K." last="Beyer">Mona K. Beyer</name><name sortKey="Bronnick, Kolbjorn" sort="Bronnick, Kolbjorn" uniqKey="Bronnick K" first="Kolbjorn" last="Bronnick">Kolbjorn Bronnick</name><name sortKey="Dalaker, Turi O" sort="Dalaker, Turi O" uniqKey="Dalaker T" first="Turi O." last="Dalaker">Turi O. Dalaker</name><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><name sortKey="Larsen, Jan P" sort="Larsen, Jan P" uniqKey="Larsen J" first="Jan P." last="Larsen">Jan P. Larsen</name><name sortKey="Tysnes, Ole Jorn" sort="Tysnes, Ole Jorn" uniqKey="Tysnes O" first="Ole-Bjorn" last="Tysnes">Ole-Bjorn Tysnes</name><name sortKey="Tysnes, Ole Jorn" sort="Tysnes, Ole Jorn" uniqKey="Tysnes O" first="Ole-Bjorn" last="Tysnes">Ole-Bjorn Tysnes</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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